Grow Your Brain Cells
The Revolution has begun, but correlation does not equal causation so let's dive in and find out the beginning as to why exercise not only helps our brains develop, but also assists with the actual growth of our brain cells. Thats right, your brain can keep producing new cells! Who knew?!...not my 4th grade teacher Mrs. Talbott, that's for sure. So let's begin.
We do know now that our brain is flexible, or plastic, as the chapter refers to several times and we can mold it as we provide new input. It's always being rewired, as opposed to only have one pathway to execute functions (which comes up many times in future chapters). Throughout this chapter, many neurotransmitters are named and we are initially given a few right off the bat. Glutamate, GABA (gamma aminobutyric acid), serotonin, norepinephrine, and dopamine are listed as crucial parts to learning. Glutamate stirs up activity to begin the signaling cascade and GABA clamps down the activity of the other three (and others too I believe). Serotonin is the "policeman" as it influences mood impulsivity, anger and aggressiveness (think Prozac). Norepinephrine amplifies the signals that influence attention, perception, motivation, and arousal. Dopamine is the learning, reward, attention, and movement neurotransmitter, but has different effects depending on which region of the brain uses it (a reference to Ritalin is made). These neurotransmitters are primarily manipulated with different medications that are produced. Exercise, especially that which is of the aerobic endurance type, causes the body to produce these neurotransmitters in various amounts (possible runner's high?), but really it's the bodies way of balancing these neurotransmitters.
So we have the messengers now, different areas that carry message to the various areas of the brain. When we exercise, and learn, but more so when our brain grows, what happens? Well there is a group of proteins loosely referred to as factors, the main one being BDNF (brain-derived neurotrophic factor). If neurotransmitters carry out the signaling, BDNF and its associates maintain the cell circuitry - the infrastructure. Overall it improves the function of neurons, encourages its growth, and strengthens and protects them against their natural process of death.
If you don't know already each brain cell has a few parts. The picture below really clears it up much better than I can describe.

The first article that Dr. Ratey can remember that involved exercise and BDNF was actually found in the journal Nature. It was concluded in the article that exercise caused the mice to produce BDNF (the "Miracle Grow" for the brain), especially in the hippocampus. This was such a huge connection because it gave a direct link to exercise and cognitive function! And actually this evidence was found again when it was determined that people with the least cognitive decline as they aged shared three main factors: education, self-efficacy, and exercise. As both of these topics became more popular, it was determined that BDNF was important not merely for the survival of neurons but also for their growth.
This has allowed us to come to the more common understanding that the brain is a muscle so-to-speak, and you need to use it or lose it. We can essentially produce all the BDNF we want and let our brain create new cells all day long, but if we don't apply learning (complex skill either physical or cognitive) then these neurons are not used and "fizzle out." Which is also backed up by numerous studies about an environment rich in sensory and social stimuli, even with mice. Also, if anyone is familiar with any kind of Pre-School history (as I am), this is where we got the Head Start Program that allows for sending disadvantaged children to preschool.
This is where we start to make the Body-Mind connection, albeit comes with some more hormones and scientific names. These are IGF-1 (insulin-like growth factor), VEGF (vascular endothelial growth factor), and FGF-2 (fibroblast growth factor). IFG-1 is released by the muscles when they need more fuel during activity and assists insulin to deliver glucose (sugar) to the cells, even in the brain! VEGF works to build capillaries in the body and the brain, and FGF-2 helps tissue grow and in the brain assists with the production of LTP (did we cover that one?). As we'll cover in later chapters, stress and depression play roles in lowering the production of these factors (foreshadowing, English I term).
So, how're those apples?! We know that exercise improves learning by optimizing your mind-set to improve alertness, attention, and motivation; prepares and encourages nerve cells to bind to each other; and spurs the development of new nerve cells. But there's a catch...you can't learn difficult material while you're exercising at high intensity because blood is shunted away from the prefrontal cortex, and hampers your executive function. It's only after that our cognitive flexibility, where we can shift thinking and produce a steady flow of creative thoughts, wakes up and improves. We actually do this in our PE classes. We run twice a week for 20 to 30 minutes, very similar to a study done in Japan that determined that after 12 weeks participants were able to improve their executive function. Though a complex skill activity that demands coordination, reinforces neurogenesis and BDNF production in the cerebellum. Which is why I'm ending with this quote:
"This is why learning how to play the piano makes it easier for kids to learn math. The prefrontal cortex will co-opt the mental power of the physical skills and apply it to other situations."
Your brain is full of roads...whether you walk, run, cycle, or drive on it. But I prefer to run.